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ISSN:2164-6457 (print)
ISSN:2164-6473 (online)
Journal of Applied Nonlinear Dynamics
Miguel A. F. Sanjuan (editor), Albert C.J. Luo (editor)
Miguel A. F. Sanjuan (editor)

Department of Physics, Universidad Rey Juan Carlos, 28933 Mostoles, Madrid, Spain

Email: miguel.sanjuan@urjc.es

Albert C.J. Luo (editor)

Department of Mechanical and Industrial Engineering, Southern Illinois University Ed-wardsville, IL 62026-1805, USA

Fax: +1 618 650 2555 Email: aluo@siue.edu

Dynamic Scenario in HTLV-I Infection

Journal of Applied Nonlinear Dynamics 9(3) (2020) 349--359 | DOI:10.5890/JAND.2020.09.002

Romina Cobiaga, Walter Reartes

Departamento de Matemática, Universidad Nacional del Sur, Av. Alem 1253, 8000 Bahía Blanca, Buenos Aires, Argentina

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Abstract

In this article we present a model that describes the emerging dynamic scenario of infection with the human T-cell lymphotropic virus (HTLV-I). In this model we incorporate the phase of latency in the infection of the CD4+ lymphocytes, the immune response mediated by CD8+ T lymphocytes and the possible appearance of adult T-cell leukemia (ATL). The proposed model is a six-dimensional, non-linear system of ordinary differential equations that describes the dynamic interactions among different cell types. Several types of biological implications are discussed.

Acknowledgments

We thank Ana Torresi for her help with this manuscript. Her useful comments and discussions are always greatly appreciated. The work is supported by the Universidad Nacional del Sur (Grant no.PGI 24/L096).

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