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ISSN:2164-6376 (print)
ISSN:2164-6414 (online)
Discontinuity, Nonlinearity, and Complexity

Dimitry Volchenkov (editor), Dumitru Baleanu (editor)

Dimitry Volchenkov(editor)

Mathematics & Statistics, Texas Tech University, 1108 Memorial Circle, Lubbock, TX 79409, USA

Email: dr.volchenkov@gmail.com

Dumitru Baleanu (editor)

Cankaya University, Ankara, Turkey; Institute of Space Sciences, Magurele-Bucharest, Romania

Email: dumitru.baleanu@gmail.com

Ferroptosis as a Biological Phase Transition III: Ephitelial-Mesenchymal Transition

Discontinuity, Nonlinearity, and Complexity 14(3) (2025) 549--558 | DOI:10.5890/DNC.2025.09.008

H. Suárez-Ogando$^{1}$, A. Guerra$^{1}$, R. Mansilla$^{2,3}$, J.M. Nieto-Villar$^{1\dag}$

$^{1}$ Department of Chemical-Physics, A. Alzola Group of Thermodynamics of Complex Systems of M.V. Lomonosov Chair, Faculty of Chemistry, University of Havana, Cuba

$^{2}$ Center for Interdisciplinary Research in Sciences and the Humanities (CEIICH), National Autonomous University of Mexico (UNAM), México City, 04510, México

$^{3}$ Peninsular Center for Humanities and Social Sciences (CEPHCIS), National Autonomous University of Mexico (UNAM), Merida 97150, Mexico.

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Abstract

In the present work, a model is proposed where the ferroptosis process is related to the stages of avascular and vascular tumor growth, including the process of epithelial-mesenchymal transition. It was found that the ferroptosis process induces cell death more effectively in cells with a mesenchymal phenotype. Furthermore, it was observed that for certain compositions of epithelial and mesenchymal cells the tumor growth system exhibits less complexity. From the evaluation of the entropy production rate, it was identified that an increase in the concentration of oxidized lipid peroxide species generates an increase in the robustness of the ferroptosis process, while decreasing the robustness of the epithelial-mesenchymal transition mechanism.

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